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Similarly, authors [3] of the first double-blind, randomized, placebo-controlled clinical trial of oral glutathione supplementation performed in healthy adult humans concluded that despite the biochemical plausibility, optimal dose, recommended timing of administration and appropriate choice of outcome measures, no significant changes were observed in oxidative stress biomarkers or erythrocyte glutathione concentrations following 4 weeks of oral (2 x 500mg daily) glutathione supplementation

Front Endocrinol (Lausanne) 16:1520835 Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K et al (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging