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In post-viral syndromes, chronic neuroinflammation often causes excess glutamate to accumulate in the synaptic cleft, where it becomes highly neurotoxic and overstimulates neurons to the point of cell death

G., Blackburn, A

Furthermore, studies have examined these effects in fibroblast and keratinocyte cultures, endothelial and neuronal systems, and preclinical animal models related to wound repair and tissue response