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GLP-1 therapy, often used to aid in weight loss and blood sugar management, works by mimicking the effects of glucagon-like peptide-1 (GLP-1)
Oral is another route but requires 50-150 mg per dosage
NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict
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