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Compared to healthy age-matched individuals whose samples were taken before the pandemic started in 2019, patients hospitalized with COVID-19 had significantly increased levels of oxidative stress and oxidant damage, and markedly reduced levels of glutathione

Therefore, they rely on protecting antioxidant substances synthesized and secreted by epididymal epithelial cells, including glutathione peroxidase 5 (GPX5) (Taylor et al., 2013)

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As research continues, FOXO4-DRI remains a compelling compound for ongoing laboratory investigation into senescence biology and transcriptional control mechanisms