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Those with thiamine and B12 shortages or malabsorption issues are best suited for this treatment

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PMID: 38980576 | doi:10.1007/s10787-024-01499-8 Sikiric P et al

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it did not itself change the formal Federal Register status, and it is distinct from the April 2026 FDA action below

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Above this threshold, denaturation begins

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