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In T1D, thymus-dependent tolerance and Treg function are thought to become dysfunctional, leading to the retention of autoreactive T cells that attack pancreatic islets ( Figure 2 )
Thus, these beneficial effects are interrelated and appear useful for the therapy of multiple vicious circles that may simultaneously appear in rats permanently maintained under severe intra-abdominal hypertension conditions
One common method is the intramuscular injection
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