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It helps with energy and nerve health
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The ER chaperone GRP78 (Endoplasmic reticulum chaperone BiP) is used as a marker of ER stress due to its ability to control the activation of transmembrane ER stress sensors Inositol-requiring enzyme 1 (IRE1), Protein kinase RNA-like endoplasmic reticulum kinase (PERK), and Activating transcription factor 6 (ATF6) through a binding-release mechanism 22
It remains to be determined through randomised controlled trials whether novel agents like semaglutide or tirzepatide may be of utility post-metabolic surgery
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