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For FOXO4-DRI, this modification is essential because it allows the therapeutic peptide to persist long enough in vivo to reach and enter senescent cells
Compared to exogenous recombinant GH (somatropin), Tesamorelin preserves the physiological pulsatility of endogenous secretion, maintaining better tissue response, avoiding GH-R desensitization, and presenting a more balanced metabolic profile (glycemic neutrality vs diabetogenic effect often documented with high-dose exogenous GH)
Science 367, 1434
The combination exceeds the mathematical sum of its parts, suggesting synergistic rather than merely additive effects
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