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Conclusions Across human studies, whole mushroom consumption appears safe and practically useful, with consistent reductions in triglycerides on self-chosen diets, lower fasting plasma glucose in a single healthy dietary pattern trial, limited but positive evidence for blood pressure improvements, and early signals of improved salivary IgA levels

The recent approval of nerandomilast, a selective inhibitor of PDE4 reducing the expression of inflammatory cytokines and pro-fibrotic growth factors, for the treatment of idiopathic pulmonary fibrosis (IPF) underlines the importance of targeting these two axes in fibrotic diseases [44, 45]