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This cardiovascular outcomes trial (CVOT) is the longest and largest of the three, following the regulatory precedent set by the SELECT trial for semaglutide, which established cardiovascular risk reduction as a label-worthy endpoint for GLP-1-class agents [5]
But experts say the science and the safety remain unclear
These analyses further strengthen the credibility of the associations described by multivariate regression analysis (Table 1)
Therefore, anti-inflammatory and neuroprotection effects might be exerted through inhibiting NF-B and MAPKs signaling pathways (88)
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