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Chronic complications of SCD such as recurrent episodes of priapism, asymptomatic testicular infarctions and primary hypogonadism have been described as potential etiologies of low fertility in male SCD patients
Furthermore, structureactivity relationship (SAR) investigations of ESC derivatives have demonstrated that rational structural modifications enhance therapeutic efficacy and bioavailability, parameters essential for translating discoveries into clinical applications (Garg et al
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