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Downregulation: Why Direction Matters More Than Good or Bad A common misconception is that every methylation gene variant is simply faulty. In reality, each SNP either speeds up (upregulates) or slows down (downregulates) its enzyme, and both directions carry trade-offs: Downregulating variants (like MTHFR C677T, MTRR A66G, MAT1A, COMT V158M) slow their enzyme, which can cause substrates like homocysteine or catecholamines to accumulate
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