If penetration reaches 10% of the adult population, as many analysts now consider plausible, the economic impact could double
VRK2 drives the trafficking of SLC7A11 by phosphorylation of Sec24C It is reported that vesicles derived from the ER transporting newly synthesized protein to the Golgi apparatus is driven by Coat protein complex II (COPII) [22]
The slower erosion curve for biologics (20-30% biosimilar market share after two years, versus 80-90% for small molecules) means that even after formal loss of exclusivity, the price compression that Cost Plus needs to add a drug to its formulary at a meaningful patient savings may not materialize for three to four years post-LOE
M., Diakogiannaki, E., Cameron, J., Grosse, J., Reimann, F., & Gribble, F