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However, high-dose vitamin C can cause significant local tissue irritation if it leaks outside the vein, so the distinction still matters
A more in-depth discussion of the effects of desolvation will be given in Chapter 6, discussing enzyme reaction mechanisms
For diluent-specific rules, see does bacteriostatic water need to be refrigerated
Elevations of orotate (orotic acid) are consistent with enzymatic deficiencies in this pathway or urea cycle deficiencies such as a defect in ornithine transcarbamoylase
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