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The functionality of the GIPR/CRE Luciferase Reporter HEK293 Cell Line was validated in dose-response assays using the agonists gastric inhibitory peptide (GIP), Tirzepatide, and Retatrutide

Hrabe, T

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Key considerations remain: Adverse Effects: Gastrointestinal Effects o Nausea, vomiting, abdominal pain, bloating most common and dose-related o Constipation or diarrhea due to slowed intestinal motility o Delayed gastric emptying may worsen symptoms of gastroparesis and complicate oral medication absorption Hepatobiliary & Pancreatic Risks o Gallstones (cholelithiasis) linked to rapid weight loss and altered biliary motility o Pancreatitis rare but potentially severe