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1.2 The physiology of incretins GIP (the one which provides the most of incretin effect in humans (7)) and GLP-1, are peptide hormones secreted respectively, L cells of the bowel and K cells of duodenum after assumption of carbohydrates, triglycerides, proteins or amino acids (44, 45)
Peptide stacking means using two or more peptide-based therapies within the same treatment plan
Rimonabant was authorized in Europe in 2006 as an anti-obesity medication and then withdrawn by the European Medicines Agency (EMA) in 2009 leading to the termination of the development of other cannabinoid receptor 1 (CB1) blockers for obesity [21, 22]
The mechanisms differ slightly
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