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Vitamin B12 deficiency occurs when the body does not get or absorb sufficient vitamin B12 from the food it consumes in order to operate effectively

The two are complementary in research

It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)