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Statements Author contributions GC: Conceptualization, Data curation, Investigation, Methodology, Writing original draft, Writing review & editing
Before designing the GLP-1RAs, we defined conserved sites or hotspot residues of GLP-1RAs as critical functions for target recognition, binding, and activation of the GLP-1 receptor (GLP-1R)
Both can be effective in weight loss, but in head-to-head trials, tirzepatide has a slight edge over semaglutide
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