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The American Diabetes Association guidelines emphasize individualized treatment approaches that balance efficacy with tolerability
doi: 10.1007/s13300-020-00951-6 49 PackerMButlerJFilippatosGSJamalWSalsaliASchneeJet al
The individual evidence for each compound is substantial and replicated in animal research, but the rationale for pairing them is mechanistic: it is based on what each does on its own, not on a study of the combination
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