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Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy [5] [11]
Despite advances, including the use of pericytes and astrocytes in co-culture and simulation of the effects of shear stress in microfluidic models, we feel human BBB models could still be improved
This dysfunction leads to reduced ATP production and increased ROS formation, which results in oxidative stress and neuronal damage
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