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Since this study is a chart review as opposed to a clinical trial, it is difficult to apply these results to all patients with HS taking semaglutide
This combination, sometimes called CagriSema, produced the 20%+ weight loss figures seen in the REDEFINE 1 phase III trial
In contrast, increased frontal activation and/or normalization of abnormal connectivity have been associated with improvement of pain and of sad mood (Ong et al., 2019)
This is not necessarily bad, but it does raise questions about whether GLP-1 claims mislead consumers about the actual mechanism of action
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