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In a rat model of neuropathic pain induced by tight ligation of L5/L6 spinal nerves, morroniside, administered either orally or intrathecally, dose-dependently alleviated mechanical allodynia, with comparable maximal efficacy (E max ) and an effective dose 50% (ED 50 ) values of 335 mgkg (oral) and 7.1 g (intrathecal) [73]
Abstract Background L-carnitine (LC), and its acetylated form, acetyl L-carnitine (ALC), have immense functional capabilities to regulate the oxidative and metabolic status of the female reproductive system
Additional, longer clinical trials for interventions targeting synaptic dysfunction will be required to monitor the safety of these compounds and to evaluate efficacy in larger study populations
& Levy, R
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