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Overexpression of HSP beta-1 (HSPB1) can reduce the intracellular iron concentration by inhibiting TFR1 expression, thus inhibiting ferroptosis (Fig
doi:10.1016/0022-2836(87)90191-4
Therefore, if you are on tamoxifen it may be best to avoid turmeric and curcumin (particularly in concentrated supplement form), as it can lower the concentration of endoxifen in the body such that it interferes with the therapeutic impact of the drug
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