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They also exert nephroprotective effects by reducing albuminuria and oxidative stress
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In type 2 diabetes, a deterioration of insulin secretion and the development of peripheral insulin resistance lead to the development of hyperglycaemia
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And the discontinuation rate due to adverse events runs roughly 2-3 times higher than tirzepatide at equivalent trial timepoints
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There have also been anecdotal reports of insomnia as a side effect, although the drugs manufacturer, Novo Nordisk, does not list it as a known adverse effect
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