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Sun J, Lin XM, Lu DH, Wang M, Li K, Li SR, Li ZQ, Zhu CJ, Zhang ZM, Yan CY, et al
New England Journal of Medicine 2023 03 Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial Rosenstock J, Frias J, Jastreboff AM, et al
The most commonly reported side-effects were gastrointestinal symptoms such as nausea, abdominal cramping, and diarrhea
In this setting, glutamine-derived -ketoglutaric acid (-KG) is converted to isocitrate and then to citrate through reductive carboxylation, followed by the generation of pyruvate and lactate, providing a pathway for lactate synthesis independent of glucose metabolism [4, 27]
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