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They increase everyone to the maximum dose regardless of body size, sensitivity, or how much weight loss is actually needed

Elderly patients and other special populations Older adults ( 65 years) with MASLD may experience greater gastrointestinal intolerance and dehydration risk

Medications with narrow therapeutic windows should be monitored Fatigue during initiation: Reduced caloric intake and metabolic adjustment during the first weeks of tirzepatide can temporarily worsen fatigue

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