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Several natural compounds could modulate HO-1 expression
Metformin activates AMPK, a key energy regulator that promotes autophagy, reduces senescent cells, and mimics the effects of caloric restrictionsupporting healthy aging and cellular repair
Epitalon is the synthetic, chemically defined successor to that extract, and the distinction matters when reading citations: a substantial share of the older and more dramatic findings refer to the undefined extract, not the tetrapeptide
This central action is why patients report reduced food cravings and smaller portion satisfaction even before meaningful weight loss occurs
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