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The diseased animal administered APAP showed marked degenerative and apoptotic changes within the hepatic tissues, mostly centrilobular and extended to midzonal area associated with marked cytoplasmic eosinophilia, marked nuclear pyknosis, in addition to vascular congestion of portal blood vessels and central vein, and marked mononuclear inflammatory cells mainly consisted of lymphocytes and macrophages around the portal area
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Wegovy (semaglutide) operates through an entirely different pathwayit mimics glucagon-like peptide-1 (GLP-1), a natural hormone that signals fullness to the brain and slows gastric emptying
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