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Moreover, over 40% of people who start taking GLP-1s quit the medicines within 2 years due to high costs and gastrointestinal side effects such as nausea, diarrhea, vomiting, and constipation, according to a study published in JAMA Network Open last year

This distinction is maintained throughout the manuscript to avoid conceptual dilution and to clearly differentiate between true circadian entrainment and indirect modulation of circadian function ( Age-related declines in melatonin secretion and signaling have been consistently associated with circadian rhythm dampening, sleep fragmentation, increased oxidative stress, and chronic low-grade inflammation, all hallmarks of biological aging