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Risks and Unknowns Remaining research gaps include: Long-term systemic administration data Optimal dosing strategies outside dermatology Interaction with copper metabolism disorders Comparative efficacy versus standard wound treatments Most evidence supports local, tissue specific effects rather than systemic transformation
If tolerated well, may titrate dose up to 3 mL (600mg)
This distinction matters because FDA approval involves a formal review of safety, effectiveness, manufacturing quality, labeling, and intended use
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