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GSTs containing cysteine in the active site (DHARs, GSTLs, GSTZ1, GSTF7, and GSTU19) and one GST with the ability to form heterodimers with a previously mentioned one (GSTF10 with GSTF7) were proven to undergo S-glutathionylation (Dixon and Edwards, 2010)
Indications: Treatment of orthostatic hypotension in adult patients with symptomatic neurogenic orthostatic hypotension (nOH) caused by: Parkinson's disease multiple system atrophy pure autonomic failure) dopamine beta-hydroxylase deficiency non-diabetic autonomic neuropathy Pharmacokinetics: administered orally converted by DOPA decarboxylase into norepinephrine Side Effects: A new drug
It is derived from silica
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