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The authors established FOXO4-DRI as a first-in-class senolytic peptide tool for cellular senescence research, with mechanistic selectivity grounded in the elevated FOXO4-p53 interaction in senescent versus non-senescent cells

After 4 weeks of D-galactose injections, the D-Gal group mice received intraperitoneal injections of PBS every 2 days for 4 weeks, followed by tissue collection

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