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Polypharmacology is the basis for drug repurposing: this principle asserts that a drug with multiple targets can have multiple mechanisms of action (Nowak-Sliwinska et al., 2019)
Development of Multi-Indication Products Targeting Broader Metabolic Disorders There is growing opportunity to position GLP-1 therapies as multifunctional agents beyond glycemic control
This is addressed fully in Section 9 with the NCCI bundling decision matrix
This makes it valuable in research exploring body-fat reduction, energy substrate switching, and long-term metabolic adaptation
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