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The antibiotic nitrofurantoin (NFT) was identified to stimulate de novo synthesis of glutathione in the human hepatoma cell line, HepG2, and in primary human hepatocytes

At sub-maximal doses, the combination produced greater weight reduction than either compound alone

Together, these results indicate that specific deletion of Trkb in iSPNs results in GSTO2 upregulation, which, through its DHAR activity, leads to DA dysfunction in Trkb Penk -KO mice at the pre-symptomatic stage