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APS might boost IRS-1 and Akt phosphorylation, triggering the PI3k signal transduction pathway to improve ISI by activating the angiotensin-converting enzyme 2-Ang-(17)-Mas axis and inhibiting the mTOR/4E-binding protein 1 (4EBP-1)/S6 kinase 1 (S6K1) signaling pathway (Simanshu et al., 2017
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Validated fibromyalgia-specific symptom scales or outcome measures were not available
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