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Across all demographic subgroups, GLP-1 RA users consistently exhibited an elevated risk of psychiatric diseases

The workaround: if you have a contraindication to step therapy medications (for example, cardiovascular disease that contraindicates phentermine, or chronic diarrhea that contraindicates orlistat), your provider can request a step therapy override

This pathway safely degrades homocysteinea potentially toxic byproduct of metabolisminto cysteine through two sequential enzymatic steps involving cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE)

Improved Mood: Adequate B12 levels are associated with better mood and mental health