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The trace element is a central cofactor for certain enzymes (glutathione peroxidases) that are responsible for the antioxidant function of glutathione

The lack of immunogenicity has practical implications: the peptide can be used for extended periods without loss of efficacy due to antibody neutralization, there is minimal risk of allergic or hypersensitivity reactions, and repeated treatment cycles are supported as prior exposure does not sensitize the immune system

SIRT3 also deacetylates targets such as the chaperone protein Hsp10 and the LON protease, involved in the UPR mt process 98

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