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Cytoprotection as a common denominator
And it starts with the question Sikiri couldn't let go of
This critical repair process supports much more efficient ATP (cellular energy) production, potentially raising the patient's baseline threshold for physical exertion and significantly reducing the severity, duration, and frequency of debilitating energy crashes and PEM
Crucially, HBV independently suppresses DNA repair capacity by downregulating poly(ADP-ribose) polymerase 1 (PARP1) via YTHDF2-mediated m6A methylationwithout enhancing ROS production or altering oxidative stress pathways [389, 391]
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