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Who Should Be Extra Cautious
However, the recently concluded SAVOR-TIMI 53 trial conducted on patients with T2DM with either a history of established CVD or multiple CVD risk factors, has failed to demonstrate the superiority of saxagliptin over placebo in reducing a composite end point of cardiovascular death, nonfatal MI or nonfatal ischemic stroke when added to usual care [142, 143]
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However, specific patient populations such as individuals with mutations in their glutathione synthesizing enzymes, AIDS patients, and cystic fibrosis patients can benefit from glutathione supplementation (Ashley, 2018)
