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The evaluation often incorporates indirect markers such as improved fertilization rates, successful embryo development, and clinical pregnancy rates as proxies for oocyte quality

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Patients typically present with an acute 3-4 g/dl drop in hemoglobin along with dark urine due to hemoglobinuria, elevated lactate dehydrogenase, and elevated reticulocyte count two to four days following an offending stressor

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FIGURE 1 Damage to the BBB can increase the permeability of the walls of the blood vessels within the brain, leading to the influx of neurotoxic and pro-inflammatory molecules, and invoking local inflammatory responses (Nian et al., 2020)

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