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Consistent with these findings, clinical observations in CKD cohorts have demonstrated a positive correlation between serum levels of IL-6/IL-1 and markers of erythrocyte membrane damage (e.g., increased osmotic fragility), as well as an inverse correlation with eryptosis (Mehta et al., 2017)

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Healthcare System Implications The widespread adoption of GLP-1 medications presents both opportunities and challenges for healthcare systems: a) Cost-Benefit Calculations : Although the medications themselves are expensive (ranging from $900 to $1,300 monthly without insurance coverage), their potential to reduce obesity-related healthcare costs is substantial

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