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Your healthcare provider should review your complete mental health history before starting semaglutide to ensure appropriate monitoring

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For patients with Type 2 diabetes, for people whose endogenous GLP-1 signaling is impaired, they represent a meaningful advance

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Pharmaceutical trials establishing semaglutide's safety profile used this once-weekly schedule exclusively, meaning clinical data supports this timing but not twice-weekly protocols

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Usually resolves within 2-4 weeks Constipation or diarrhea Common initially, manageable with diet and hydration Reduced appetite This is the intended effect, but some patients need guidance on maintaining adequate nutrition Injection site reactions Mild redness or swelling (uncommon) Fatigue Some patients feel tired in the first few weeks as their body adjusts to reduced caloric intake Serious side effects are rare but can include pancreatitis and gallbladder issues

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