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Diabetes Care (1992) 15:2706
AD is characterized by a decade-long prodromal stage, and dementia diagnosis typically occurs in the late biological stage of AD, by which time substantial amounts of A and tau proteins have accumulated in the cortex [101]
The large 2025 meta-analysis quantified this as approximately 63% higher gastrointestinal adverse event rates compared with placebo, and gallbladder disorders were about 26% higher
This leads to slower absorption of glucose and other macronutrients, preventing rapid blood sugar spikes
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