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Higher insulin levels and blood sugar can add to the hormone imbalances seen in PCOS as insulin stimulates the production of androgens, which cause PCOS symptoms like hirsutism, oily skin, hair loss, and acne
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30 Also, the onset of acute pancreatitis occurred after 12 months in the LEADER trial and after more than five to six months in the SCALE trial, indicating that the likelihood of developing pancreatitis was influenced more by the rate and degree of weight loss than the drug itself
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