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La segnalazione delle reazioni avverse sospette , che si verificano dopo lautorizzazione allimmissione in commercio di un farmaco, importante in quanto permette un monitoraggio continuo del rapporto beneficio/rischio dello stesso
In routine care, approved medicines should follow the product label and a clinicians assessment
The key findings relevant to this question: No clinically relevant drug-metabolizing enzyme-mediated interactions have been reported for GLP-1 agonists Some transporters (OATP1B1/3, OAT3) showed inhibition with GLP-1 agonist treatment in vitro Significant changes in oral contraceptive and levothyroxine absorption were documented with tirzepatide and oral semaglutide GLP-1 agonists delay gastric emptying, which can alter absorption of co-administered oral medications Critically, no published study has examined the drug-drug interaction profile of two injectable GLP-1 agonists administered concurrently
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