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& Defranco, A
8-week on, 4-week off example: Weeks 1-2: Assessment and dose finding (every other day) Weeks 3-6: Optimization phase (3-5 times weekly) Weeks 7-8: Maintenance (3 times weekly) Weeks 9-12: Complete break, no DSIP During the off period, focus on sleep hygiene fundamentals: consistent wake times, light exposure management, temperature optimization, and stress reduction
All subjects were divided into different groups, where one group was presented with the peptide gel, whereas others were given standard care with a placebo application
Gastrointestinal discomfort is transient in most reports, resolving within the first week of administration without dose adjustment
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