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Leveraging the GLP-1 receptor structure for drug discovery
Gottschalck IB, Jeppesen PB, Hartmann B, Holst JJ, Henriksen DB
The 22-nt long mature miRNA strand obtained from the intermediate duplex is then loaded into the Argonaute-containing RNA-induced silencing complex (RISC) and target mRNA molecules by miRNA:mRNA sequence complementarity and negatively affects gene expression either through mRNA cleavage and degradation via the perfect base-pairing with target mRNA or translation repression via imperfect complementation with 3UTR of target mRNA (Llave et al., 2002
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