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In a notable phase II clinical trial published in The Lancet (2008), Tesofensine demonstrated dose-dependent weight loss of up to 10.6% over 24 weeks in obese individualssubstantially higher than placebo or many existing weight-loss drugs
Studies examining links between TB500 and integrin linked kinase suggest potential involvement in pathways related to cell adhesion, structural organization, and communication between cells and their surrounding matrix
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