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3 % can be used for mature or sun-damaged skin under clinician guidance
The reaction is catalyzed by pyridoxal 5-phosphate (PLP)-dependent L-seryl-tRNASec selenium transferase and uses selenophosphate (monoselenium phosphate) as the selenium donor ( Figure 4 ) (26)
Low responders may benefit from switching to oral minoxidil under medical supervision, which bypasses the follicular conversion step, though this introduces different risk considerations
May result in homocysteine accumulation and impaired methylation
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