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They are highly toxic to the liver and are amongst the major identified risk factors for hepatocellular carcinoma 10,11,12
2005;10(Suppl 2):M1259
mTORC1 directly phosphorylates ribosomal protein S6 kinase 1 (S6K1) and/or eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) to increase translation, including translation of metabolic enzymes and metabolism-related transcription factors (Saxton and Sabatini, 2017)
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